UV Spectrophotometric method has been developed for simultaneous estimation of Paracetamol (PCM) and Tapentadol Hydrochloride (TP) in bulk drug and in Pharmaceutical dosage form. This method utilizes methanol as a solvent and λmax of Paracetamol and Tapentadol is selected for analysis was found to be 249 nm and 274 nm respectively. Linearity was observed in the concentration range of 4-12 μg/ml for Paracetamol (r2=0.999) and 30-70 μg/ml for Tapentadol (r2=0.999). The method was validated statistically and by recovery studies. The mean % recovery was 99.63-100.83 % and 98.30-100.98 % for Paracetamol and Tapentadol respectively. Developed method was applied to pharmaceutical dosage form. The results were found to be within acceptance criteria according to ICH guideline. This method was simple, rapid, accurate and sensitive.
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